Kappa/Lambda Ratios In IgG, IgA and IgM of Cerebrospinal Fluid and of Sera in Patients with Multiple Sclerosis

Abstract

Kappa/lambda (κ/λ) ratios of each immunoglobulin, i.e. IgG, IgA and IgM in cerebrospinal fluid (CSF) and in sera of patients with multiple sclerosis (MS) were analysed by sandwich enzyme linked immunosorbent assay. In CSF κ/λ ratios of IgG of MS patients were significantly (p < 0.05) higher than those of normal controls, whereas the values of IgA and IgM did not differ significantly from those of normal controls. In sera κ/λ ratios of IgG, IgA and IgM did not differ significantly from those of normal controls. Our results suggest that in MS patients abnormal κ/λ ratios are also restricted to IgG components in CSF, as oligoclonal IgG bands are.

Key Words:

• CSF
• immunoglobulins
• light-chain ratios
• multiple sclerosis