Analyses of Broncho Alveolar Lav Age Fluid (BALF) in MRL-LPR/LPR Mice

Masatoshi Takaishi Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

Yukikazu Awaya Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

Shinichi Ishioka Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

Soichiro Hozawa Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

Tetsu Oyama Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

Kouichi Takahashi Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

Hiroyuki Maeda Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

Michio Yamakido Department of Clinical Pathology and 2nd Department of Internal Medicine, School of Medicine, Hiroshima University, Hiroshima

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Abstract

We performed bronchoalveolar lavage (BAL) in MRL-lpr/lpr (MRL/I) and MRL - +/+ (MRL/n) mice and evaluated various cellular and humoral components of the bronchoalveolar lavage fluid (BALF) to clarify the pathogenic mechanism of pulmonary fibrosis in MRL/l mouse. The numbers of macrophages, neutrophils and lymphocytes, N-Acetyl-β-glucosaminidase (β-NAG), and fibronectin increased in the BALF from MRL/l mice than that from MRL/n mice, but no significant differences were observed in total protein, β-glucuronidase, acid phosphatase, or phospholipid level. Increased fibronectin level in the BALF from MRL/l mice may be related with pathogenesis of pulmonary fibrosis.

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Analyses of Broncho Alveolar Lav Age Fluid (BALF) in MRL-LPR/LPR Mice

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Analyses of Broncho Alveolar Lav Age Fluid (BALF) in MRL-LPR/LPR Mice

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