Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders and Non-Thyroid Autoimmune Diseases

U. Feldt-Rasmussen Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

M. Høier-Madsen Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

K. Bech Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

M. Blichert-Toft Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

H. Bliddal Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

J. Date Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

B. Danneskiold-samsøe Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

L. Hegedüs Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

E. Hippe Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

P. J. Hornnes Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

N. J. Kriegbaum Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

M. Müller Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

H. Perrild Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

N. G. Rasmussen Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

B. Rasmusson Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

A. Schouboe Depts of Med F and Oncol R, Herlev Univ Hosp, Autoimmune Lab, State Serum Inst, Dept of Med E and Rheumatol, Frederiksberg Hosp, Steno Memorial Hosp, Depts of Obstet and Gynaecol, Gentofte Univ Hospital and State Hosp, Dept of Med C, Gentofte Univ Hosp, Dept of Med TTA, State Hosp, Dept of Med C, Bispebjerg Hosp, Copenhagen University, Depts of Surg and Clin Chem, Odense Univ, Hosp, Denmark

show all

Abstract

A new commercial method for measurement of anti-thyroid peroxidase (anti-TPO DYNOtest, Henning, Berlin) was evaluated in normal subjects and in patients with autoimmune thyroid and non-thyroid diseases, and compared to an immune fluorescence method for measurement of anti-microsomal antibodies (MicAb), and a radioimmunological method for quantifying thyroglobulin antibodies (TgAb). The majority of normal subjects had anti-TPO levels below 52 U/ml and patients with Hashimoto's thyroiditis had levels above 200 U/ml, with a good correlation to MicAb. In other autoimmune thyroid diseases the correlation was less pronounced. In non-thyroid autoimmune diseases MicAb showed falsely positive reactions in the presence of other autoantibodies, e. g. mitochondrial antibodies. The present study indicates that the anti-TPO method should probably replace measurements of MicAb for routine clinical use, thus providing a sensitive, precise, antigen specific method with the ability to reveal quantitative fluctuations. The study also indicates that TgAb could be abolished in routine diagnosis of autoimmune thyroid diseases and be reserved for special clinical situations, research purposes as well as measurement in sera before evaluation of serum thyroglobulin levels.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders and Non-Thyroid Autoimmune Diseases

Information for

Open access

Opportunities

Help and information

Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders and Non-Thyroid Autoimmune Diseases

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature