Anti-Epstein-Barr Virus-Nuclear Antigen-1,-2A and-2B Antibodies in Rheumatoid Arthritis Patients and Their Relatives

Pierre Youinou Laboratory of Immunology, Brest University Medical School Hospital, Brest, France

Marlyse Buisson Laboratory of Virology, Grenoble University Medical School Hosptial, Grenoble, France

Jean-Marie Berthelot Laboratory of Immunology, Brest University Medical School Hospital, Brest, France

Christophe Jamin Laboratory of Immunology, Brest University Medical School Hospital, Brest, France

Paul Le Goff Unit of Rheumatology, Brest University Medical School Hospital, Brest, France

Odile Genoulaz Laboratory of Virology, Grenoble University Medical School Hosptial, Grenoble, France

Armelle Labour Laboratory of Immunology, Brest University Medical School Hospital, Brest, France

Peter M. Lydyard Department of Immunology, University College and Middlesex School of Medicine, London, UK

Jean-Marie Seigneurin Laboratory of Virology, Grenoble University Medical School Hosptial, Grenoble, France

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Abstract

We have examined serum antibodies to Epstein-Barr virus Nuclear Antigen (EBNA)-1,-2A and-2B, in addition to antibodies to viral capsid antigen and early antigen in 100 rheumatoid arthritis patients and 50 of their relatives. Using indirect immunofluorescence on transfected cells and Western-blot technique, we have found increased frequency and litres of antibodies to EBNA-2B in patients and, to a lesser degree, in their family members, whereas other anti-Epstein-Barr virus antibodies appeared to be similar to controls. Cross-inhibition experiments were carried out and show that antibodies to EBNA-2A are distinct from those to-2B, and vice verse.

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Anti-Epstein-Barr Virus-Nuclear Antigen-1,-2A and-2B Antibodies in Rheumatoid Arthritis Patients and Their Relatives

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Anti-Epstein-Barr Virus-Nuclear Antigen-1,-2A and-2B Antibodies in Rheumatoid Arthritis Patients and Their Relatives

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