Polymorphism Study of Tcr α and γ Genes in Insulin Dependent Diabetes Mellitus (Iddm) Multiplex Families

Abstract

T-cell receptor (TCR)α and γ genes polymorphisms were analysed by Restriction Fragment Length Polymorphism (RFLP) in 10 Insulin Dependent Diabetes Mellitus (IDDM) multiplex families. TCRα and γ alleles distribution does not significantly differ between affected and non affected children. Furthermore there was no excess of Cα or V γallele sharing in affected sib pairs. Therefore the T-cell receptor α and γ chain alleles studied do not seem to affect IDDM susceptibility per se.

Key Words:

• Insulin dependent diabetes mellitus IDDM
• T-cell Receptor TCR
• multiplex families
• RFLP