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Abstract
T-cell receptor (TCR)α and γ genes polymorphisms were analysed by Restriction Fragment Length Polymorphism (RFLP) in 10 Insulin Dependent Diabetes Mellitus (IDDM) multiplex families. TCRα and γ alleles distribution does not significantly differ between affected and non affected children. Furthermore there was no excess of Cα or V γallele sharing in affected sib pairs. Therefore the T-cell receptor α and γ chain alleles studied do not seem to affect IDDM susceptibility per se.