Update Mediators of Joint Swelling and Damage in Rheumatoid Arthritis and Pristane Induced Arthritis

C. J. Elson Departments of Pathology and Microbiology and Pharmacology, School of Medical Sciences, University of Bristol

S. J. Thompson Departments of Pathology and Microbiology and Pharmacology, School of Medical Sciences, University of Bristol

C. I. Westacott Departments of Pathology and Microbiology and Pharmacology, School of Medical Sciences, University of Bristol

K. D. Bhoola Departments of Pathology and Microbiology and Pharmacology, School of Medical Sciences, University of Bristol

Abstract

Joint swelling and tenderness in rheumatoid arthritis (RA) probably result from IgG aggregates activating complement with the consequent attraction of polymorphonuclear leucocytes (PMNs) and the liberation of their granule enzymes such as kininogenases. By contrast IL-1 and TNF are the major stimulants of cartilage and bone loss although other agents contribute. The fundamental drive for the production of these mediators is unknown but a role for heat shock proteins is suggested from work on pristane induced arthritis.

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Update Mediators of Joint Swelling and Damage in Rheumatoid Arthritis and Pristane Induced Arthritis

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Update Mediators of Joint Swelling and Damage in Rheumatoid Arthritis and Pristane Induced Arthritis

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