21
Views
59
CrossRef citations to date
0
Altmetric
Original Article

Cytokine Expression in Labial Salivary Glands from Patients with Primary Sjöugren's Syndrome

, &
Pages 185-191 | Received 07 Sep 1991, Accepted 07 Jan 1992, Published online: 07 Jul 2009
 

Abstract

The presence and distribution of 7 cytokines was examined immunohistologically in labial salivary gland (LSG) specimens from patients with primary Sögren's syndrome (SS) and control subjects. The cytokines interleukin (IL)-1βIL-6, tumor necrosis factor (TNF)α and interferon (IFN)γ were identified in defined parts of LSG from patients but not in the corresponding parts of control glands: (a) LSG acinar epithelium expressed IL-1β, (b) blood vessels located in both normal LSG stroma and within lymphocytic infiltrates expressed IL-lβ, IL-6 and IFNm`, and (c) lymphocytic infiltrates expressed IL-lβ, IL-6 and TNFα. All four cytokines were expressed by salivary ducts within both patient and control specimens, but with generally greater intensity in patients. IL-lα, IL-4 and TNFβ (lymphotoxin) could not be detected in any of the specimens from patients or controls. The locations of cytokines in LSG suggests possible mechanisms of immunologically mediated parenchymal damage in primary SS.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.