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Original Article

T Cell Receptor β Gene Polymorphism and Rheumatoid Arthritis

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Pages 75-77 | Received 28 Oct 1991, Accepted 07 Nov 1991, Published online: 07 Jul 2009
 

Abstract

Susceptibility to rheumatoid arthritis is, in part, conferred by genetic factors. Previous studies have suggested that inheritance of a particular allele of a restriction fragment length polymorphism (RFLP) detected in the T cell receptor β (TCRβ) gene complex is associated with rheumatoid arthritis (RA). We have specifically tested this hypothesis in ethnically and geographically matched populations of RA patients and controls. We were unable to confirm previous observations of a TCRβ association with RA even after stratifying our study and control populations by HLA type.

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