14
Views
8
CrossRef citations to date
0
Altmetric
Original Article

Histological Characteristics of Lupus Nephritis in Fl Mice With Chronic Graft-Versus-Host Reaction Across MHC Class II Difference

, , , , , & show all
Pages 79-87 | Received 27 Sep 1991, Accepted 12 Dec 1991, Published online: 07 Jul 2009
 

Abstract

Renal lesions at the chronic phase of MHC class-II-disparate graft-versus-host reaction (GVHR) were examined. To induce GVHR, C57BL/6 (B6) spleen cells were injected twice into either (B6xbml2)F1 (class-II-disparate), (B6xbml)F1 (class-I-disparate) or (bmlxbml2)Fl mice (class-I+II-disparate). for comparison, (C57BL/10xDBA/2)F1 (BDF1) mice injected with DBA/2 spleen cells were also used.

(B6xbml2)F1 and BDF1 recipients showed marked elevation of anti-DNA antibodies, circulating immune complexes (CIC) and the number of immunoglobulin producing cells (IgPC). At 20 weeks after cell injection, severe immune complex glomerulonephritis (ICGN) was observed in (B6xbml2)F1 recipients, but was far less severe in (bmlxbml2)F1 recipients and was not observed in (B6xbml)F1 recipients. ICGN was also observed in BDF1 recipients at 12 weeks after cell injection. By immunofluorescent microscopy, IC deposition was detected along the capillary loops and also in the mesangial area in (B6xbml2)F1 recipients, while BDF1 recipients showed only a capillary pattern. By light microscopy, the renal lesion of (B6xbml2)Fl recipients appeared similar to those of BDF1 recipients. Histologically, (B6xbml2)F1 recipients serve as a good model for lupus glomerulonephritis induced by class-II-disparate GVHR.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.