Lack of Disease Recurrence in Diabetic BB/PFD Rats After Syngeneic Islet Transplantation

B. Kuttler Division of Medical Cell Biology, Institute of Diabetes “Gerhardt Katsch”, University of Greifswald, Germany

C. Mathieu Laboratory for Experimental Medicine and Endocrinology (LEGENDO), U.Z. Gasthuisberg, Catholic University of Leuven, Belgium

M. Waer Laboratory of Immunopathology, Rega Institute, Catholic University of Leuven, Belgium

H. J. Hahn Division of Medical Cell Biology, Institute of Diabetes “Gerhardt Katsch”, University of Greifswald, Germany

R. Bouillon Laboratory for Experimental Medicine and Endocrinology (LEGENDO), U.Z. Gasthuisberg, Catholic University of Leuven, Belgium

Abstract

Restimulation of autoreactivity in two different BB rat sublines of the same origin (Ottawa, Canada) was investigated by syngeneic islet transplantation into diabetic animals. Despite identical methods and conditions recurrence of hyperglycaemia was observed in BB/OK rats (Karlsburg, Germany) but not in BB/Pfd rats (Leuven, Belgium). Pancreatic morphology at the time of transplantation revealed significant differences in islet volume density and the degree of insulitis. Additionally, marked differences in the phenotypical composition of cells infiltrating the islets were observed. A loss of autoimmune memory in BB/Pfd rats is discussed as a probable reason for the lack of disease recurrence in those animals.

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Lack of Disease Recurrence in Diabetic BB/PFD Rats After Syngeneic Islet Transplantation

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Lack of Disease Recurrence in Diabetic BB/PFD Rats After Syngeneic Islet Transplantation

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