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Original Article

The Role of Hsp90 in Sle

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Pages 211-218 | Received 14 Nov 1994, Published online: 07 Jul 2009
 

Abstract

The heat shock proteins are a group of evolutionarily conserved proteins with important physiological functions, whose synthesis is enhanced by elevated temperature or other stresses. A role for one or more of these proteins in human autoimmune disease has been extensively discussed. This review considers the evidence of a role for hsp90 in systemic lupus erythematosus (SLE) where over-expression of this protein, its surface localization and auto-antibodies to it have been observed in both human patients and in the MRL/1pr mouse model of SLE.

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