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Autoimmunity Volume 18, 1994 - Issue 2
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Original Article

Autoimmune Thrombocytopenia: Anti-Glycoprotein IIb/IIIa Auto Antibodies are Reduced after Human Anti-D Immunoglobulin Treatment

B. J. Boughton Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham, B15 2TH, United Kingdom
,
R. M. S. Cooke Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham, B15 2TH, United Kingdom
,
N. A. Smith Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham, B15 2TH, United Kingdom
,
A. W. Simpson Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham, B15 2TH, United Kingdom
,
Yukihito Sato Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham, B15 2TH, United Kingdom
,
Akira Matsumori Department ofHaematology, University of Birmingham Medical School Edgbaston Birmingham, B15 2TH, United Kingdom
&
Shigetake Sasayama The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University, Kyoto, Japan
 show all
Pages 141-144 | Published online: 07 Jul 2009
 
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Abstract

In chronic autoimmune thrombocytopenic purpura (AITP), an indirect monoclonal antibody immobilised platelet antigen (MAIPA) assay detected serum glycoprotein (GP) Ilb/IIIa antibodies in 16/39 (41%) cases. In patients with clinically active AITP, a direct MAIPA assay detected platelet-associated GP Ilb/IIIa kantibodies in 8/13 (62%) cases. Platelet bound and serum antibody concentrations suggested a high antibody affinity for platelet membrane glycoprotein Ilb/IIIa. Five AITP patients with platelet associated glycoprotein Ilb/IIIa antibodies were treated with intravenous anti D immunoglobulin. All showed an increase in platelet counts and a decrease in platelet associated autoantibody. These responses could be due to immunosuppressive anti-idiotype antibodies in anti D immunoglobulin.

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