The Study of Anticardiolipin Antibodies and Interleukin-6 in Cerebrospinal Fluid and Blood of Chinese Patients with Systemic Lupus Erythematosus and Central Nervous System Involvement

Tsann-Sheng Yeh Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Chrong-Reen Wang Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Geng-Wang Jeng Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Gwon-Loon Lee Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Mao-Yuan Chen Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Gong-Ren Wang Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Kuei-Tang Lin Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Che-Yen Chuang Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

Chen-Yen Chen Sections of Rheumatology and Immunology, Department of Internal Medicine, College of Medicine, National Taiwan University, Taipei

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Abstract

Anticardiolipin (ACL) antibodies and interleukin-6 (IL-6) in cerebrospinal fluid (CSF) may be involved in the mechanism of lupus patients with central nervous system (CNS) involvement. ACL antibodies of 3 isotypes and IL-6 were measured in paired CSF and serum samples from 14 lupus patients with CNS involvement, 5 lupus patients without CNS involvement and 7 patients with non-inflammatory neurological diseases. ACL antibodies, IgG and IgM isotypes, and IL-6 were significantly increased in CSF from lupus patients with CNS involvement as compared with other 2 groups of patients. Both ACL antibodies and IL-6 decreased after neurological activity subsided. These results suggest increased ACL antibodies and IL-6 in CSF are involved in immune responses within CNS in lupus patients. Quantitation of CSF ACL antibodies may be helpful in evaluating neurological activity of lupus patients with CNS involvement.

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The Study of Anticardiolipin Antibodies and Interleukin-6 in Cerebrospinal Fluid and Blood of Chinese Patients with Systemic Lupus Erythematosus and Central Nervous System Involvement

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The Study of Anticardiolipin Antibodies and Interleukin-6 in Cerebrospinal Fluid and Blood of Chinese Patients with Systemic Lupus Erythematosus and Central Nervous System Involvement

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