Skip to Main Content

15

Views

1

CrossRef citations to date

0

Altmetric

Original Article

Involvement of t cell immunity in the transient thyroid inflammation induced by iodide in goitrous balb/c and nude mice

F. Neu Laboratory of Histology, Catholic University of Louvain, Medical School, Brussels, Belgium

,

T. Rebai Laboratory of Histology, Catholic University of Louvain, Medical School, Brussels, Belgium

,

J. F. Denef Laboratory of Histology, Catholic University of Louvain, Medical School, Brussels, Belgium

&

M. C. Many Laboratory of Histology, Catholic University of Louvain, Medical School, Brussels, Belgium

Abstract

To evaluate the involvement of T cell immunity in the thyroiditis induced in goitrous mice by iodide administration, we analyzed the immunological changes happening in the thyroid glands and lymph nodes during goiter involution in balb/c and athymic nude mice of similar background.

In both balb/c and nude mice, goiter involution was characterized by thyroid cell necrosis and inflammation. In balb/c mice, the inflammatory infiltrate was made of numerous Ia⁺ cells. Their number was unchanged during goiter development, but was significantly increased after 2 days of involution and remained high after 8 days. CD4 + and CD8 + T cells were also observed, some of which were clearly activated since they expressed the receptor for Interleukin-2 (IL-2R). The numbers of CD4 +, CD8 + and IL-2 R + T cells were increased during goiter as compared to control mice, and they reached a maximum at day 1 of involution.

In nude mice, unexpectedly, CD4 + and CD8 + T cells were also found in the thyroid. Their numbers, as well as the number of la + cells, were significantly increased at the onset of involution, but they remained systematically lower than in the corresponding groups of balb/c mice.

Iodide treatment of goitrous mice also induced modifications of the lymph nodes draining the thyroid: enlargement of the paracortical T zone, presence of germinal centers in cortical follicles, and increase of the density of IL-2 R + cells. Mesenteric lymph nodes taken as controls were unchanged.

Thus, three observations suggest the involvement of T cell immunity in iodine-induced thyroid inflammation: 1. Infiltration of Ia +, CD4 +, CD8 + and IL-2 R+ cells. 2. Signs of stimulation in thyroid lymph nodes, 3. Significant differences between balb/c and nude mice, in which the inflammatory reaction is weaker.

Key Words:

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.