HLA Typing of a Family with Systemic Lupus Erythematosus

Hideo Kagawa First Department of Internal Medicine, Kansai Medical University, Osaka, Japan

Yoshio Ozaki First Department of Internal Medicine, Kansai Medical University, Osaka, Japan

Kazutaka Uehira First Department of Internal Medicine, Kansai Medical University, Osaka, Japan

Shosaku Nomura First Department of Internal Medicine, Kansai Medical University, Osaka, Japan; Department of Blood Transfusion, Kansai Medical University, Osaka, Japan

Tatsunoki Matsuzaki Department of Blood Transfusion, Kansai Medical University, Osaka, Japan

Tomoko Ishida Department of Blood Transfusion, Kansai Medical University, Osaka, Japan

Shirou Fukuhara First Department of Internal Medicine, Kansai Medical University, Osaka, Japan; Department of Blood Transfusion, Kansai Medical University, Osaka, Japan

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Abstract

Although systemic lupus erythematosus (SLE) is a representative collagen disease, the etiology remains unclear. However, both genetic and environmental factors seem to be involved. Based on serological studies, associations between certain human leukocyte antigens and many autoimmune diseases have long been suggested. Regarding the genetic aspects of SLE, the HLA haplotype is regarded as a potentially important factor, although its role remains controversial. Recently, we examined three family members who had SLE with an identical HLA haplotype.

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HLA Typing of a Family with Systemic Lupus Erythematosus

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HLA Typing of a Family with Systemic Lupus Erythematosus

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