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Autoimmunity Volume 24, 1996 - Issue 2
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Original Article

Efficacy of Low Dose Prednisone Plus Aspirin in Preventing Spontaneous Abortions and/or Fetal Deaths Due to Antiphospholipid Antibodies: Results of a Pilot Study

M. G. Mazzucconi Haematology, Department of Human Biopathology, University ‘La Sapienza’, Rome, Italy
,
F. Dragoni Haematology, Department of Human Biopathology, University ‘La Sapienza’, Rome, Italy
,
A. Chistolini Haematology, Department of Human Biopathology, University ‘La Sapienza’, Rome, Italy
,
M. Peraino Haematology, Department of Human Biopathology, University ‘La Sapienza’, Rome, Italy
,
R. Paesano II Obstetrical and Gynaecologital Clinic, University ‘La Sapienza’, Rome, Italy
,
M. Di Prima Autoimmunity Service, Institute Tropical Disease, University ‘La Sapienza’, Rome, Italy
,
F. Di Francesco II Obstetrical and Gynaecologital Clinic, University ‘La Sapienza’, Rome, Italy
,
C. Masala Autoimmunity Service, Institute Tropical Disease, University ‘La Sapienza’, Rome, Italy
&
A. Pachi' II Obstetrical and Gynaecologital Clinic, University ‘La Sapienza’, Rome, Italy
 show all
Pages 123-125 | Received 20 May 1996, Accepted 20 May 1996, Published online: 07 Jul 2009
 
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Abstract

Antiphospholipid antibodies (APA) are a group of autoantibodies, including lupus anticoagulant (LA) and anticardiolipin antibodies (ACA), able to interfere with the coagulation system1. The presence of these autoantibodies has been related to the occurrence of arteriovenous thromboses, thrombocytopenia and fetal losses also in patients without diagnosis of systemic lupus erythematous (SLE)2. In order to reduce the pregnancy complications in patients with APA several prophylactic approaches have been proposed as successful treatment3,4. The majority of these prophylactic approaches had utilized intermediate- high dose prednisone and/or aspirin.

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