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Original Article

HLA-DR and the Development of Rheumatoid Arthritis

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Pages 123-128 | Received 13 Jan 1997, Accepted 23 Feb 1997, Published online: 07 Jul 2009
 

Abstract

Susceptibility to develop Rheumatoid arthritis (RA) maps to a highly conserved amino acid motif (“the shared epitope”) expressed in the third hypervariable region of different HLA-DRB1 alleles. This motif, namely QKRAA, QRRAA or RRRAA helps the development of RA by an unknown mechanism.

However, it is now established that the shared epitope can 1/ Shape the T cell repertoire 2/ Interact with 70 kD heat shock proteins

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