Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process

L. C. Gahring Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) and University of Utah School of Medicine, Salt Lake City, UT, 84112, USA

N. G. Carlson Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) and University of Utah School of Medicine, Salt Lake City, UT, 84112, USA

S. W. Rogers Salt Lake City Veteran's Administration Geriatrics Research, Education and Clinical Center (GRECC) and University of Utah School of Medicine, Salt Lake City, UT, 84112, USACorrespondence[email protected]

Abstract

Anti-glutamate receptor (GluR) agonist-like antibodies prepared in rabbits that are similar to autoantibodies found in Rasmussen's encephalitis (RE) were found to exhibit greater immunoreactivity towards human interferon alpha receptor (IFNAR-1) than to GluR3. Since antibodies prepared to a defined region of GluR3 can react preferentially to an unrelated sequence in the human IFNAR-1, we propose that the IFNAR-1 may be an heteroclitic antigen of GluR3. These results suggest that differential reactivity toward heteroclitic antigens may contribute to variable clinical characteristics of certain autoimmune diseases.

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Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process

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Antibodies Prepared to Neuronal Glutamate Receptor Subunit3 Bind IFNα-Receptors: Implications for an Autoimmune Process

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