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Research Article

Anti-allergic effect of lambertianic acid from Thuja orientalis in mouse bone marrow-derived mast cells

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Pages 250-255 | Received 19 Feb 2010, Accepted 24 May 2010, Published online: 19 Aug 2011
 

Abstract

Lambertianic acid is a bioactive diterpene found in the leaves of Thuja orientalis. Its effect on the bone marrow-derived mast cell (BMMC) mediated allergy and inflammation mechanism remains unknown. In this study, lambertianic acid was evaluated for its effect on the allergic mediators, including prostaglandin D2 (PGD2), leukotriene C4 (LTC4), β-hexosaminidase (β-Hex) and cyclooxygenase-2 (COX-2) protein, in phorbol 12-myristate 13-acetate (PMA) plus calcimycin-stimulated BMMCs. The results revealed that lambertianic acid inhibited the production of interleukin-6 (IL-6), PGD2 and LTC4, the expression of COX-2 and the degranulation of β-hexosaminidase in the PMA plus calcimycin-induced BMMCs. Taken together, these findings implied that lambertianic acid may possess the potential in the treatment of allergy.

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