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Research Article

Cytostatic Effects of Activated Macrophages on Tumor Target Cells: Inhibition of Cytotoxic Action of Ara-C

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Pages 325-348 | Published online: 28 Sep 2008
 

Abstract

Studies carried out to explore further the cytotoxic effects of activated macrophages from mice treated with Corynebacterium parvum revealed that their effect on the EMT-6 line of tumor target cells was limited solely to cytostasis with no evidence of a cytocidal effect. In additional studies, the cytostatic effects of activated macrophages markedly reduced the cytotoxic effects of the chemotherapeutic agent cytosine arabinoside on EMT-6 target cells.

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