Immunostimulating Substances from Human Casein

P. Jolles Laboratory of Proteins, University of Paris V, 45 rue des Saints-Peres, F 75270, Paris; Centre Nicolas Grillet, Rhočne-Poulenc Recherches et Développement, F 94400, Vitry-sur-Seine, France

F. Parker Laboratory of Proteins, University of Paris V, 45 rue des Saints-Peres, F 75270, Paris; Centre Nicolas Grillet, Rhočne-Poulenc Recherches et Développement, F 94400, Vitry-sur-Seine, France

F. Floc'h Laboratory of Proteins, University of Paris V, 45 rue des Saints-Peres, F 75270, Paris; Centre Nicolas Grillet, Rhočne-Poulenc Recherches et Développement, F 94400, Vitry-sur-Seine, France

D. Migliore Laboratory of Proteins, University of Paris V, 45 rue des Saints-Peres, F 75270, Paris; Centre Nicolas Grillet, Rhočne-Poulenc Recherches et Développement, F 94400, Vitry-sur-Seine, France

P. Alliel Laboratory of Proteins, University of Paris V, 45 rue des Saints-Peres, F 75270, Paris; Centre Nicolas Grillet, Rhočne-Poulenc Recherches et Développement, F 94400, Vitry-sur-Seine, France

A. Zerial Laboratory of Proteins, University of Paris V, 45 rue des Saints-Peres, F 75270, Paris; Centre Nicolas Grillet, Rhočne-Poulenc Recherches et Développement, F 94400, Vitry-sur-Seine, France

G. H. Werner Laboratory of Proteins, University of Paris V, 45 rue des Saints-Peres, F 75270, Paris; Centre Nicolas Grillet, Rhočne-Poulenc Recherches et Développement, F 94400, Vitry-sur-Seine, France

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Abstract

Delipidated human casein was digested with trypsin and the enzymatic digest was fractionated on Sephadex G-50. The peptidic fractions were assayed for immunomodulating activity in two in vitro models. Fractions corresponding to molecular weights in the range of 2,000 ± 600 were found to possess stimulating activity in these models.

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Immunostimulating Substances from Human Casein

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Immunostimulating Substances from Human Casein

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