Development of a Bioassay for Anti Tumor Activity of Biological Response Modifiers of the Reticuloendothelial Stimulant Class: Reproducibility of the Bioassay

J. W. Proctor Allegheny-Singer Research Corporation, Radiation Research Laboratories, Allegheny General Hospital, Pittsburgh, PA, 15212; Department of Basic Microbiology and Clinical Immunology, Medical University of South Carolina, Charleston, SC

Y. Yamamura Department of Basic Microbiology and Clinical Immunology, Medical University of South Carolina, Charleston, SC; Department of Physiology, Tulane University Medical School, New Orleans, LA

N. R. Diluzio Department of Physiology, Tulane University Medical School, New Orleans, LA

P. W. A. Mansell Comprehensive Cancer Center for the State of Florida, University of Miami School of Medicine Miami, FL

Abstract

Intravenously administered DiLuzio glucan, Wellcome C. parvum, and Glaxo BCG caused dose dependent increases in the tumor cell loss from the lungs of C57BL/6J and DBA/2J mice challenged respectively with intravenous ¹²⁵IuDR labelled B16 or T 1699 mammary carcinoma cells.

The results were reproducible with respect to the optimal doses and the magnitudes and shapes of the dose response curves.

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Development of a Bioassay for Anti Tumor Activity of Biological Response Modifiers of the Reticuloendothelial Stimulant Class: Reproducibility of the Bioassay

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Development of a Bioassay for Anti Tumor Activity of Biological Response Modifiers of the Reticuloendothelial Stimulant Class: Reproducibility of the Bioassay

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