Isradipine Inhibits PMN Leukocyte Function. A Possible Interference with the Adenosine System

Abstract

The dihydropyridine derivative isradipine is able to inhibit PMN leukocyte function, such as enzyme release and free radical generation, fallowing the activation with specific stimuli. Moreover, the drug prevents calcium influx into the cells as detected by the specific fluorescent dye FURA 2/acetoxymethylester. The specific adenosine receptor antagonist theophylline is able to partially remove the inhibiting activity, thus suggesting a possible interference of isradipine with the adenosine system. Such a cell-protecting activity adds further rationale to the employement of isradipine in those conditions, such as acute and chronic ischaemia and reperfusion damage, in which PMN leukocyte-dependent tissue injury represents a relevant pathogenetic mechanism.