Inhibiting Effects of Serotonin and Serotonin Antagonists on the Migration of Mononuclear Leucocytes

Abstract

The effect of serotonin and the serotonin antagonists ketanserin, methiotepine and ICS-205-930 on the migration of leucocytes was studied by using the sealed capillary migration technique. The migration of mononuclear leucocytes was inhibited by serotonin at lO⁻⁴and 10⁻⁶-10⁻¹⁰mol/l. An inhibition of the mononuclear leucocyte migration was also caused by ICS-205-930 at 10 ⁴mol/l, ketanserin at 10⁻⁴and 10⁻⁸-10⁻¹⁰mol/l and methiotepine at 10⁻⁴and 10⁻⁶-10⁻⁸mol/l. No inhibiting effects of serotonin or the serotonin antagonists were found on the migration of polymorphonuclear leucocytes. Thus, both serotonin and serotonin antagonists may inhibit mononuclear leucocyte migration.