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Abstract
γ-HCH (Lindane) is reported to cause a biphasic immuno-modulation-stimulation followed by supression-after oral administration in mice (1). Role of calcium in this biphasic immuno-modulation. was. assessed after 4,12 and 24 wks of γ-HCH administration.45Ca-uptake was enhanced during the initial immuno-stimulation followed by decrease concomitant with immunosuppression. Lymphocyte proliferation was inhibited during both the phases of immune response by verapamil, a calcium channel blocker, and by trifluoperazine, a calmodulin inhibitor. These findings show an impairment of calcium homeostasis in lymphocytes culminating into the biphasic immunomodulatory effects of γ-HCH.