Polymorphonuclear Phagocytosis and Killing in Workers Occupationally Exposed to Hexachlorobenzene

Mary L.S. Queiroz Department of Pharmacology/Hemocentre-Faculty of Medical Sciences—University of Campinas, PO Box 6111, CEP, 113084-100, Campinas, SP, Brazil, xx 55 19 2393181/xx 55 19 253 3606 [email protected]

Marlene R. Quadras Department of Pharmacology/Hemocentre-Faculty of Medical Sciences—University of Campinas, PO Box 6111, CEP, 113084-100, Campinas, SP, Brazil, xx 55 19 2393181/xx 55 19 253 3606 [email protected]

Marize C. Valadares Department of Pharmacology/Hemocentre-Faculty of Medical Sciences—University of Campinas, PO Box 6111, CEP, 113084-100, Campinas, SP, Brazil, xx 55 19 2393181/xx 55 19 253 3606 [email protected]

Josiane P. Silveira Department of Pharmacology/Hemocentre-Faculty of Medical Sciences—University of Campinas, PO Box 6111, CEP, 113084-100, Campinas, SP, Brazil, xx 55 19 2393181/xx 55 19 253 3606 [email protected]

Abstract

Phagocytosis and intracellular killing of Candida albicans and Candida pseudotropicalis by neutrophils from 66 workers exposed to chlorinated compounds were studied. Phagocytosis with both antigens was normal in all the workers studied. However, lytic activity of the neutrophils in the presence of both antigens, C. albicans and C. pseudotropicalis was impaired. These findings might be related to a derangement in the antioxidant mechanisms and to some interference with GSH levels that might lead to the abnormal functions observed in neutrophils.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Polymorphonuclear Phagocytosis and Killing in Workers Occupationally Exposed to Hexachlorobenzene

Information for

Open access

Opportunities

Help and information

Polymorphonuclear Phagocytosis and Killing in Workers Occupationally Exposed to Hexachlorobenzene

Abstract

Reprints and Corporate Permissions

Academic Permissions

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Your download is now in progress and you may close this window

Login or register to access this feature