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Immunopharmacology and Immunotoxicology Volume 21, 1999 - Issue 4
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Research Article

Eft of Schizonepeta Tenuifolia Extract On Mast Cell-Mediated Immediate-Type Hypersensitivity In Rats

Tae-Yong Shin College of Pharmacy, Woosuk University, Wanju, Chonbuk, 565-701, South Korea
,
Hyun-Ja Jeong Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan-city, Chonbuk, 570-749, South Korea
,
Sug-Min Jun Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan-city, Chonbuk, 570-749, South Korea
,
Han-Jung Chae Department of Dental Pharmacology, School of Dentistry, Wonkwang University, Iksan-city, Chonbuk, 570-749, South Korea
,
Hyung-Ryong Kim Department of Dental Pharmacology, School of Dentistry, Wonkwang University, Iksan-city, Chonbuk, 570-749, South Korea
,
Seung-Hwa Back Devision of Chemistry, Technical & Biological Science, College of Natural Sciences, Wonkwang University, Iksan-city, Chonbuk, 570-749, South Korea
&
Hyung-Min Kim Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan-city, Chonbuk, 570-749, South Korea
 show all
Pages 705-715 | Published online: 27 Sep 2008
 
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Abstract

We investigated the effect of an aqueous extract of Schizonepeta tenuifolia (STAE) on mast cell-mediated immediate-type hypersensitivity. STAE inhibited systemic allergic reaction induced by compound 48/80 in rats dose-dependently. STAE also inhibited plasma histamine levels induced by compound 48/80. STAE inhibited local allergic reaction activated by anti-dinitrophenyl (DNP) IgE. In addition, STAE does-dependently inhibited histamine release from rat peritoneal mast cells (RPMC) activated by compound 48/80 or anti-DNP IgE. However, STAE had a significant enhancing effect on anti-DNP IgE-induced tumor necrosis factor-α (TNF-α) production from RPMC. These results indicate that STAE inhibits immediate-type hypersensitivity and suggest that STAE can selectively activate the TNF-α production from RPMC.

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Related Research Data

Immunomodulation Effects of Schizonepeta tenuifolia Briq. on the IgE-Induced Allergic Model of RBL-2H3 Cells.
Source: Hindawi Limited

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