Canine Pancreaticoduodenal Allotransplantation: A Preparation for Human Pancreatic Transplantation

Abstract

This canine pancreaticodunodenal autotransplantation model includes virtually the entire pancreas attached to a duodenal cuff (second portion). The blood supply is based on the superior pancreaticoduodenal artery and the venous outflow on the gastroduodenal vein. The vascular anastomoses are end-to-side to the external iliac artery and vein. Exocrine drainage is channeled through the bladder from the transplanted duodenum. This technique closely resembles whole-organ pancreas transplant in humans with a cystoduodenostomy. The bowel reconstruction consists of a Billroth I gastroduodenostomy and a cholecystoduodenostomy. The entire procedure is relatively free of major complications and may be performed in less than 4 hours

Key Words:

• pancreaticoduodenal
• autotransplantation
• gastroduodenostomy
• cholecystoduodenostomy
• cystoduodenostomy