A Porcine Model for the Study of Liver Regeneration

D. Kahn Department of Surgery and Medical Research Council Liver Research Group, University of Cape Town Observatory, 7925, Cape Town, South Africa

R. Hickman Department of Surgery and Medical Research Council Liver Research Group, University of Cape Town Observatory, 7925, Cape Town, South Africa

J. Terblanche Department of Surgery and Medical Research Council Liver Research Group, University of Cape Town Observatory, 7925, Cape Town, South Africa

Abstract

A technique of 65% partial hepatectomy in the pig is described. Thymidine kinase activity and mitotic index were used as indices of liver regeneration. Thymidine kinase activity increased from a baseline value of 1526 ± 256 to a maximum of 23992 ± 4966 dpm/mg protein on the third day after partial hepatectomy. The mitotic index also increased from 0–13.3 ± 1.66 on the third postoperative day. The indices of regeneration remained unchanged after sham operation

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A Porcine Model for the Study of Liver Regeneration

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A Porcine Model for the Study of Liver Regeneration

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