An Animal Model for Small-Diameter Arterial Grafts

William S. Cassel Department of Surgery, Division of Vascular Surgery State, University of New York Stony Brook, New York

Robert A. Mason Department of Surgery, Division of Vascular Surgery State, University of New York Stony Brook, New York

Ruth Campbell Department of Surgery, Division of Vascular Surgery State, University of New York Stony Brook, New York

G. Broadie Newton Department of Surgery, Division of Vascular Surgery State, University of New York Stony Brook, New York

John C.K. Hui Department of Surgery, Division of Vascular Surgery State, University of New York Stony Brook, New York

Fabio Giron Department of Surgery, Division of Vascular Surgery State, University of New York Stony Brook, New York

Abstract

A rabbit model was developed to study small-diameter arterial grafts. A total of 158 2-mm-diameter polytetrafluoroethylene (PTFE) grafts und 35 autogenous carotid artery (AA) grafts were interposed in the carotid arteries of New Zealand white rabbits. A pilot study of 16 PTFE grafts used to develop operative and anesthetic techniques had a 20% mortality and 38% early (<2 day) thrombosis rate. Subsequent to the pilot study 177 grafts were placed and a 92% postoperative survival with 100% AA graft patency and 93% PTFE graft patency at 2 weeks was observed. AA grafts followed beyond 16 weeks continued to have 100% patency, while PTFE grafts began to show increased failure. Closure was found to be due to the development of anastomotic myointimal hyperplasia.

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An Animal Model for Small-Diameter Arterial Grafts

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An Animal Model for Small-Diameter Arterial Grafts

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