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ABSTRACT
Background and Aims: The aim of our study was to investigate whether medium-chain triglyceride (MCT) and protein-enriched enteral nutrition (EN) could improve protein level and clinical outcomes in postoperative patients with gastrointestinal cancer. Material and Methods: A randomized clinical trial was performed. A population of 229 patients with gastrointestinal cancer was enrolled and allocated to two groups: (a) 114 patients received MCT and protein-enriched EN (Group I) and (b) 115 patients received an isocaloric EN (Group II). The total calorie was 25 kcal/kg/day and the time period of full dose of EN must be at least five days. Results: The three plasma proteins were improved after the EN support in both groups (p < .05). But, the increase of prealbumin in Group I was higher than that in Group II (p < .05). Episodes of diarrhea rate were equal and the postoperative infectious complications were not different between both groups. The length of hospital stay was shorter in Group I (18.4 ± 12 vs. 24.5 ± 15 d; p < .05). Conclusions: MCT and protein-enriched EN improves the prealbumin level and shortens the length of hospital stay in patients with gastrointestinal cancer without a high rate of adverse reaction, which may be due to high content of MCT and protein in EN.
ACKNOWLEDGEMENTS
The authors gratefully acknowledge Academician Jieshou Li for providing excellent comments on the study design.