Use of Sodium Hetastarch (Hespan) Solution for Reduction of Postoperative Adhesion Formation in Rabbits

Richard S. Gist Sheppard Air Force Base Hospital, Department of Obstetrics and Gynecology Sheppard AFB, Texas, USA

Peter Y. Lu Mayo Graduate School of Medicine, Department of Obstetrics and Gynecology Division of Reproductive Endocrinology Rochester, Minnesota, USA

H. G. Madhwa Raj Louisiana State University School of Medicine, Department of Obstetrics and Gynecology, Louisiana, New Orleans, USA

Charles Campbell Louisiana State University School of Medicine, Department of Obstetrics and Gynecology, Louisiana, New Orleans, USA

Thomas E. Elkins Louisiana State University School of Medicine, Department of Obstetrics and Gynecology, Louisiana, New Orleans, USA

Abstract

A study was conducted to determine the effect of sodium hydroxy ethyl starch (Hespan) on primary adhesion formation in a rabbit model. Hespan is a readily available volume expander. This was a randomized, double-blinded animal model in which New Zealand white rabbits were subjected to midline celiotomy. Adhesions were created by abrasion in both uterine horns, adjacent bowel, and peritoneum. Necropsies were performed at the 2-week interval and adhesions were graded. Significant decreases in type II and type III adhesions (p =. 032 and p =. 020, respectively) were demonstrated in Hespan-treated animals. Sodium hetastarch appears to decrease signifcant adhesion formation in treated animais and may have a roie as an adjunct for postsurgical prevention.

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Use of Sodium Hetastarch (Hespan) Solution for Reduction of Postoperative Adhesion Formation in Rabbits

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Use of Sodium Hetastarch (Hespan) Solution for Reduction of Postoperative Adhesion Formation in Rabbits

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