Glucose Suppresses the Activity of Rat Oxyntic Histidine Decarboxylase Without Affecting Gastrin Levels

Abstract

Glucose suppressed the activity of oxyntic mucosal histidine decarboxylase within 2 h when given either intragastrically or intraperitoneally to rats fasted for 24 h. Serum levels of gastrin, secretin, glucagon, and somatostatin and oxyntic mucosal levels of gastrin, histamine, and somatostatin showed no significant changes after glucose. Glucose suppressed the aspirin-induced histidine decarboxylase activity without changing serum gastrin. It also suppressed the pentagastrin-induced histidine decarboxylase activity. Neither fructose nor mannitol had such an effect. These results suggest that glucose acts directly on the enterochromaffin-like cells in rat oxyntic mucosa to suppress histidine decarboxylase activation.

Key Words:

• enterochromaffin-like cell
• gastrointestinal hormones
• glucose
• histidine decarboxylase