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Inhalation Toxicology
International Forum for Respiratory Research
Volume 26, 2014 - Issue 7
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Research Article

Episodic ozone exposure in adult and senescent Brown Norway rats: acute and delayed effect on heart rate, core temperature and motor activity

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Pages 380-390 | Received 18 Sep 2013, Accepted 14 Mar 2014, Published online: 29 Apr 2014
 

Abstract

Setting exposure standards for environmental pollutants may consider the aged as a susceptible population but the few published studies assessing susceptibility of the aged to air pollutants are inconsistent. Episodic ozone (O3) is more reflective of potential exposures occurring in human populations and could be more harmful to the aged. This study used radiotelemetry to monitor heart rate (HR), core temperature (Tc) and motor activity (MA) in adult (9–12 months) and senescent (20–24 months) male, Brown Norway rats exposed to episodic O3 (6 h/day of 1 ppm O3 for 2 consecutive days/week for 13 weeks). Acute O3 initially led to marked drops in HR and Tc. As exposures progressed each week, there was diminution in the hypothermic and bradycardic effects of O3. Senescent rats were less affected than adults. Acute responses were exacerbated on the second day of O3 exposure with adults exhibiting greater sensitivity. During recovery following 2 d of O3, adult and senescent rats exhibited an elevated Tc and HR during the day but not at night, an effect that persisted for at least 48 h after O3 exposure. MA was elevated in adults but not senescent rats during recovery from O3. Overall, acute effects of O3, including reductions in HR and Tc, were attenuated in senescent rats. Autonomic responses during recovery, included an elevation in Tc with a pattern akin to that of a fever and rise in HR that were independent of age. An attenuated inflammatory response to O3 in senescent rats may explain the relatively heightened physiological response to O3 in younger rats.

Acknowledgements

The authors thank Drs Aimen Farraj and Gary Hatch for their review of the manuscript. The authors also thank D. Terrell for providing technical assistance in the operation of the exposure system.

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