Abstract
Male and female Fischer 344 rats, female C57BU6 mice, and male and female beagle dogs were divided into three treatment groups and exposed nearly continuously (23 h/day, 7 days/wk) to IP-4 jet fuel vapor at concentrations of 0, 500, and 1000 mg/m3 for 90 days. At exposure termination, all dogs and one-third of the rodents were euthanized and the remaining animals were held for either a 19- or 21 -mo postexposure tumorigenesis observation period. Pathologic findings in male rats revealed treatment-related renal toxicity consistent with male rat α2μ-globulin nephropathy. No treatment-related respiratory toxicity was noted in any species. This study did not demonstrate target-organ toxicity or carcinogenesis that could be extrapolated to other species.