The applied biochemistry of PEDF and implications for tissue homeostasis

Abstract

Pigment epithelium-derived factor (PEDF) is an endogenously produced glycoprotein with a spectrum of biological roles across diverse pathologies. Recent research has focused on the biochemical properties of PEDF and its associated receptors. This review discusses the recent developments in PEDF biochemistry and how this new knowledge will help progress our understanding of PEDF as a molecular mediator for anti-angiogenesis and -tumorigenesis. Additionally, pathophysiological roles for PEDF in healing and tissue homeostasis are being revealed and our enhanced understanding of the interactions between PEDF and its receptors may yet prove useful in propelling PEDF towards clinical application.

Keywords::

• Pigment epithelium-derived factor
• structure
• receptor
• biochemistry
• healing
• repair

Acknowledgements

Dr M. L. Broadhead is supported by a Postgraduate Scholarship awarded by the National Health and Medical Research Council (NHMRC). The authors would also like to acknowledge the continuing support of the Royal Australasian College of Surgeons, the Australian Orthopaedic Association and the St Vincent's Research Endowment Fund.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.