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Abstract
Gynecological tumors are major therapeutic areas of platinum-based anticancer drugs. Here, we report the characterization and in vitro biological assays of cisplatin-containing Egg L-α-phosphatidylcholine liposomes with different amounts of cholesterol. Dynamic light scattering estimated sizes of all obtained liposomes in the 100 nm range that are suitable for in vivo use. On the basis of these data and of the drug loading values, the best formulation has been selected. Stability and drug release properties of platinum-containing liposomes have been verified in serum. The growth inhibitory effects of both liposomal and free drug in a panel of ovarian and breast human cancer cell lines, characterized by a different drug sensitivity, give comparable or better results with respect to free cisplatin drug.
Declaration of interest
The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.
They are also indebted with the Italian Minister for Research (M.I.U.R.) for financial supports under PRIN 2009WCNS5C. This research was funded by Regione Campania under POR Campania FESR 2007–2013 – O.O. 2.1 (FarmaBioNet).