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Abstract
The distribution of small neutral liposomes from phosphatidylcholine (PC) and cholesterol (Choi), 7:5 molar ratio, when transplanting skin and renal grafts administered locally, intavenously (IV), and subcutaneously (SC) to determine the regularities of their delivery to the pathological nidus and their accumulation in the liver has been studied. It is stated that the liposome uptake by the skin allograft after SC injection is different from the one by the skin autograft in its more prolonged growth of radioactivity. The local injection of liposomes after renal transplantation also results in prolonged liposome uptake by the graft and regional lymph nodes. Liposomes uptake by the allograft after IV injection is found to take place during the first day both for skin and renal transplantation. It is evident that SC and local injections are the varieties of the lymphogenic way of liposome administration. When using liposomes containing immunosuppressants and antiischemic drugs lymphgeneous and IV administrations when combined can be effective.