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Abstract
The exact mechanism of liposome formation is still not well understood. When starting from lipid-in-water suspensions there are predominantly two different mechanisms of vesicle formation: fragmentation of bilayers with subsequent self-closure of bilayered fragments and budding off daughter vesicles from mother liposomes. The two mechanisms are qualitatively discussed and related to particular vesicle preparation methods. The article is concluded with a speculative unifying mechanism and discussion on liposome stability.