Giant Cobblestone-like Papillae During Isotretinoin Therapy

Abstract

Purpose: To report a case of giant cobblestone-like papillae that appeared during oral isotretinoin therapy.

Design: Case report.

Methods: A 14-year-old boy presented with bilateral eye itching for 1 week. Bilateral upper palpebral conjunctival cobblestone-like papillae, superficial punctate keratitis, and shield ulcer in the left cornea were seen. At the time, he was treated with oral isotretinoin for 6 months.

Results: Following cessation of isotretinoin, the ulcer and SPK healed, and the papillae disappeared completely after an 8-week course.

Conclusion: Giant cobblestone-like papillae and corneal shield ulcer may be considered as a probable isotretinoin-induced ocular adverse event.

KEYWORDS::

• Acne
• adverse events
• cobblestone-like papillae
• corneal shield ulcer
• isotretinoin

ACKNOWLEDGMENT

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.