Clinical Outcomes of Patients with Vogt–Koyanagi–Harada Disease Over 12 Years at a Tertiary Center

Abstract

Purpose: To describe the clinical characteristics and treatment outcomes of Vogt–Koyanagi–Harada (VKH) disease over a 12-year period.

Methods: A retrospective chart review was used to identify VKH patients, from January 1999 to December 2011.

Results: In total, 154 patients (308 eyes) were diagnosed with VKH. The mean age at diagnosis was 33.8 ± 13 years. Mean baseline best-corrected visual acuity (BCVA) was 20/125; (0.8 ± 0.6 logMAR). Recurrent episodes occurred in 107 (54%) patients. Oral prednisone was administered in all patients. At the last visit, the mean BCVA was 20/50 (0.4 ± 0.7 logMAR). The most common complications post-treatment were: glaucoma [104 (33.8%) eyes] and cataract [84 (27.2%) eyes].

Conclusions: In Saudi Arabia, VKH-related uveitis is predominant in young females. Bilateral panuveitis is the most common ocular manifestation and near 50% of eyes present with exudative retinal detachment. Oral prednisone was the primary treatment and the majority of eyes maintained 20/50 or better vision.

Keywords:

• Panuveitis
• prednisone
• Saudi Arabia
• uveitis
• Vogt–Koyanagi–Harada disease

Declaration of Interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Notes

Presented in part at the Joint Meeting of the American Academy of Ophthalmology and the Asia-Pacific Academy of Ophthalmology, Chicago, Illinois, USA, November 2012.