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Original Article

Strategies of Digital Fundus Photography for Screening Diabetic Retinopathy in a Diabetic Population in Urban China

, , , , , , , & show all
Pages 414-419 | Received 11 Nov 2010, Accepted 29 Mar 2012, Published online: 21 Nov 2012
 

Abstract

Purpose: To evaluate the effect of mydriasis and different field strategies on technical failure, probability to refer diabetic retinopathy (DR, sensitivity) and probability not to refer patients without DR (specificity) of digital photography in screening with a fundus camera.

Methods: A total of 531 patients with diabetes underwent fundus photography with cross-combinations of mydriasis/nonmydriasis and single-field/two-field strategies, followed by slit lamp biomicroscopic examination by a trained ophthalmologist. Fundus photographs were graded independently by another experienced ophthalmologist. Calculations were first based on cases with non-gradable images treated as being referred and then with them excluded.

Results: Percentages of DR and referable DR in this patient cohort were 22.4% and 7.7%, respectively, based on slit lamp biomicroscopic examination. Mydriasis significantly reduced the technical failure rate from 27.1% to 8.3% under a single-field strategy, and from 28.2% to 8.9% under a two-field strategy. As compared to the single-field strategy, the two-field strategy increased sensitivity from 75.6% to 87.8% without mydriasis and from 73.2% to 90.2% with mydriasis. Mydriasis increased specificity from 68.8% to 84.3% in the single-field strategy and from 64.7% to 81.6% in the two-field strategy. Had the subjects with non-gradable images been excluded, the two-field strategy without mydriasis reported sensitivity of 85.7% and specificity of 91.6%.

Conclusions: Both mydriasis and the two-field strategy are useful in photographic screening tests. Technical failure should be taken into consideration when screening strategies for DR are determined.

ACKNOWLEDGMENTS

The authors would like to express their appreciation to all the participants in the study. The authors would also like to thank Alan Geater, Rassamee Sangthong, and Edward McNeil for their valuable help and advice. This paper is part of the first author’s thesis to fulfill the requirements for a Masters Degree in Epidemiology at the Epidemiology Unit, Prince of Songkla University.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the article. This work was supported by the Norwegian Fredskorpset Exchange Program, the Norwegian Research Council Grant (FRIMED ES426990), Tsinghua-Yue-Yuen Medical Sciences Fund (Grant 20240000564) and the National Basic Research Program of China (973 Program) Grant 2007CB512201.

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