Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss

Ryo TsutsumiDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Akihisa FujimotoDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, JapanCorrespondence[email protected]

Yutaka OsugaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Miyuki HaradaDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Yuri TakemuraDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Minako KoizumiDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Tetsu YanoDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

Yuji TaketaniDepartment of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

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Abstract

We describe successful ovulation induction with low-dose hCG administration in addition to hMG in a patient with refractory hypothalamic amenorrhea. A 24-year-old woman with weight loss-related amenorrhea underwent ovulation induction and intracytoplasmic sperm injection (ICSI). Administration of exogenous gonadotropins was ineffective in ovulation induction. Supplementation with low-dose hCG in order to increase luteinizing hormone (LH) activity in the late follicular phase produced late folliculogenesis and steroidogenesis, and ovulation was then successfully induced. This report reacknowledges the critical role that LH plays cooperatively with follicle-stimulating hormone in both folliculogenesis and steroidogenesis.

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Declaration of Interest: The authors declare no conflicts of interest.

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Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss

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Successful pregnancy following low-dose hCG administration in addition to hMG in a patient with hypothalamic amenorrhea due to weight loss

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