Studies of cardiovascular risk factors in polycystic ovary syndrome patients combined with subclinical hypothyroidism

Abstract

Objective: To investigate cardiovascular risk factors in women with polycystic ovary syndrome (PCOS) combined with subclinical hypothyroidism (SCH). Patients: A place-controlled study was performed. Group 1: 29 patients with PCOS and SCH; Group II: 35 patients with PCOS and normal thyroid function; and Group III: 34 healthy women with normal thyroid function.

Main measure indexes: Total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), Carotid Arterial Intima-Media Thickness (CIMT), free triiodothyronine 3 (FT3), free triiodothyronine 4 (FT4), thyroid stimulating hormone (TSH), fasting glucose, 1-hour oral glucose tolerance test (OGTT1), 2-hour oral glucose tolerance test (OGTT2), fasting insulin, insulin after 1 hour oral glucose (INS1), insulin after 2 h oral glucose (INS2), HOM-IR = (fasting glucose × fasting insulin)/22.5.

Results: TG, TC FIN, INS1, and HOM-IR levels were significantly higher, but the mean HDL level was significantly lower in Group I than in Group II (p < 0.05). LDL cholesterol, FGOGTT1, OGTT2, and insulin after 2 h oral glucose were not significantly higher in Group I than in Group II (p > 0.05). TG, TC, FIN and INS contents 2 h meal, HOM-IR levels were significantly higher, and the mean HDL cholesterol level was significantly lower in Group I than in Group III (p < 0.05). Blood glucose levels after 1 and 2 h were not significantly higher in Group I than in the Group III (p > 0.05). Carotid Arterial Intima-Media Thickness (CIMT) was significantly thicker in Group I than other two groups.

Conclusions: The PCOS patients combined with SCH have higher risk of cardiovascular risk factors than in controls or in patients with PCOS.

Chinese abstract

目的：探讨合并有亚临床甲减（subclinical hypothyroidism，SCH）的多囊卵巢综合征（polycystic ovary syndrome，PCOS）患者的心血管危险因素。患者：研究对象为就诊于同一医院的患者。组1：合并有亚临床甲减的PCOS患者29名；组2：甲状腺功能正常的PCOS患者35名；组3：甲状腺功能正常的健康女性34名。

主要测量指标：总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride ，TG)、低密度脂蛋白（low-density lipoprotein，LDL)、高密度脂蛋白（high-density lipoprotein，HDL）、颈动脉内膜中层厚度（Carotid Arterial Intima-Media Thickness，CIMT）、游离三碘甲状腺氨酸（free triiodothyronine 3，FT3）、游离甲状腺素（FT4）、促甲状腺激素（thyroid stimulating hormone，TSH）、空腹血糖（fasting glucose，FG）、口服葡萄糖耐量试验1小时和2小时血糖（oral glucose tolerance test，OGTT1和OGTT2）、空腹胰岛素（fasting insulin，FIN）、口服葡萄糖1小时和2小时血胰岛素（INS1、INS2）、胰岛素抵抗指数（HOM-IR）=（空腹血糖×空腹胰岛素）/22.5。

结果：组1与组2相比，组1的TG、TC、FIN、INS1、HOM-IR显著升高，HDL水平明显降低（p<0.05）；LDL、FG、OGTT1、OGTT2、INS2并无显著升高（p＞0.05）。组1与组3相比，组1的TG、TC、FIN、INS2、HOM-IR显著升高，HDL水平显著降低（p<0.05），OGTT1和OGTT2并不显著升高（p＞0.05）。组1的CIMT比组2和组3显著增厚。

结论：与健康女性或单纯PCOS患者相比，合并有亚临床甲减的PCOS患者心血管危险因素更高。

• Blood pressure
• carotid arterial intima-media thickness
• insulin release test
• lipid parameters
• oral glucose tolerance test
• polycystic ovary syndrome
• resting heart rate
• subclinical hypothyroidism