Is there any relationship between cardiovascular risk markers and young women with diminished ovarian reserve?

Abstract

Objective: It has been widely known that cardiovascular disease (CVD) risk is increased in menopause. The aim of the study was to evaluate whether this risk was elevated in young women with diminished ovarian reserve (DOR).

Methods: A hundred women with DOR and 100 women with normal ovarian reserve (NOR) attending the infertility unit at Suleymaniye Maternity, Research &Training Hospital, were enrolled in the study. CVD risk markers such as insulin resistance (defined by the homeostasis model assessment ratio [HOMA-IR]), C-reactive protein (CRP), low-density lipoprotein (LDL), high-density lipoprotein (HDL), total cholesterol (TC), and triglyceride (TG) were assessed.

Results: HOMA-IR, CRP, TG, LDL levels were higher and HDL was lower among patients with DOR compared to the controls (p < 0.05 for all). There were positive associations between DOR and HOMA-IR, CRP, TG, LDL levels and a negative correlation with HDL (p < 0.05 for all). However, multivariate logistic regression analysis showed that HOMA-IR, CRP, TG, and HDL were independent variables that were associated with DOR.

Conclusions: CVD risk markers were increased in women with DOR. Further studies with larger groups are needed to investigate the nature of the link in these patients.

Chinese abstract

目的：现在广泛认为心血管系统疾病（cardiovascular disease，CVD)）发生风险在更年期增加。本研究的目的旨在探索在伴有卵巢储备功能减退（diminished ovarian reserve，DOR）的年轻女性中其发生风险是否也会升高。方法：本试验共纳入了在苏莱曼尼耶妇产医院—研究教学医院，生殖中心就诊的100名伴有DOR以及100名卵巢储备功能正常（normal ovarian reserve ，NOR)）的女性。对CVD风险标志物例如胰岛素抵抗[主要通过稳态模式评估法计算胰岛素抵抗指数（HOMA-IR）]，C反应蛋白（CRP），低密度脂蛋白（LDL），高密度脂蛋白（HDL），总胆固醇（TC）以及甘油三酯（TG）水平进行评估。结果：DOR女性与对照组女性相比，前者HOMA-IR，CRP，TG，LDL水平较高，HDL水平较低（(p<0.05）。DOR与HOMA-IR，CRP，TG，LDL水平之间存在正相关，与HDL间存在负相关（(p<0.05）。然而，多变量逻辑回归分析指出HOMA-IR，CRP，TG,及HDL为独立变量，与DOR有关。结论：CVD风险标志物在DOR女性中升高。进一步的研究需要更大的样本量，以揭示这些患者中关联的性质。

• Cardiovascular risk
• C-reactive protein
• diminished ovarian reserve
• dyslipidemia
• insulin resistance