Metabolic disorder and obesity in 5027 Brazilian postmenopausal women

Abstract

Objectives: To evaluate the frequency of obesity in postmenopausal women and assess the potential effects of increased body mass index (BMI) on lipoprotein profile and on risk factors for arterial hypertension and diabetes.

Design: A cross-sectional study was conducted with 5027 postmenopausal Brazilian women. Analyses were performed of BMI and cardiovascular factors (systemic blood pressure [BP], total cholesterol, low-density lipoprotein, high-density lipoprotein [HDL-C], triglyceride, and fast glucose). The statistical analysis included the chi-square and Mann-Whitney tests. The significance level was set at 5%.

Results: Obesity (BMI >30) in our study characterized approximately 30% of the 5027 postmenopausal women. The comparison of patients with normal BMI and those with high BMI showed that high BMI had a significant negative effect on BP, as evidenced by the increased frequency of hypertension in overweight and obese patients (>25) (p < 0.001), that it also negatively and significantly affected triglyceride (p < 0.001) and fast glucose levels (p < 0.001), and that it was linked significantly to low levels of HDL-C.

Conclusion: Our data showed the high frequency of obesity in our population and of the cardiovascular risks (glucose, systemic arterial hypertension, and low HDL-C) associated with high BMI.

Chinese abstract

目的：评估绝经后女性的肥胖发生率，以及体重指数（BMI）增加对脂类代谢和动脉性高血压、糖尿病的危险因素的潜在影响。

实验设计：5027名巴西绝经后女性参与完成了一项横断面研究。分析BMI和心血管疾病危险因素（系统性高血压[BP]，总胆固醇，低密度脂蛋白，高密度脂蛋白[HDL-C]，甘油三酯和空腹血糖）。统计分析包括卡方检验和曼-惠特尼检验。显著性水平设定在5%。

结果：参与实验的5027名绝经后女性中有约30%的人有肥胖（BMI>30）。比较BMI正常的患者和高BMI的患者发现，高BMI患者在BP方面有显著的负面影响，超重和肥胖病人中高血压发生率增加可作为证明 (>25) (p<0.001)，同时对甘油三酯水平(p<0.001)和空腹血糖水平(p<0.001)也有负面且显著的影响，且与低水平HDL-C也有显著地相关性。

结论：数据显示，人群中肥胖高发生率和心血管疾病危险因素（血糖，系统性和低HDL-C）增加都与高BMI相关。

• Menopause
• metabolic disorder
• obesity