Gonadotroph adenoma causing ovarian hyperstimulation syndrome in a premenopausal woman

ABSTRACT

Introduction: Gonadotroph adenomas occur commonly in middle-aged adults without any specific endocrinological symptoms. To date, only 30 cases of gonadotropinoma causing ovarian hyperstimulation syndrome in pre-menopausal women have been reported.

Case report: A 37-year old woman with pituitary macroadenoma and hyperprolactinaemia was admitted to the Department of Endocrinology, Diabetology and Isotope Therapy. She presented with recurrent ovarian cysts, menstrual disturbances, headaches, visual impairment and galactorrhea. Her endocrine profile showed normal values of FSH, elevated concentrations of estradiol and suppressed LH levels. Transsphenoidal resection of the tumor tissue resulted in normalization of the hormone values and improvement in the clinical picture.

Conclusions: Gonadotroph adenomas should be considered in the differential diagnosis in premenopausal women with OHSS.

Chinese abstract

引言：促性腺激素腺瘤常见于中年人且没有任何特殊的内分泌相关症状。目前为止，也只有30例绝经前妇女促性腺激素腺瘤引起卵巢过度刺激综合征的报道。

个案报道：一名37岁妇女因垂体大腺瘤和高泌乳素血症到妇科内分泌、糖尿病及同位素门诊就诊。她叙述自己所患的卵巢囊肿已复发，同时还有月经紊乱、头痛、视力减退和溢乳的症状。其性激素检查显示FSH水平正常、雌激素浓度升高、LH水平降低。经蝶骨切除垂体腺瘤术后激素水平恢复正常，同时临床症状也得到改善。

结论：绝经前妇女发生卵巢过度刺激综合征时应考虑与促性腺激素腺瘤相鉴别。

• α-Subunit
• estradiol
• gonadotroph adenoma
• follicle-stimulating hormone
• luteinizing hormone
• ovarian hyperstimulation syndrome