New trends of progestins treatment of endometriosis

Abstract

The management of endometriosis with OC or progestins is generally safe, effective and well-tolerated and should constitute the first line of medical treatment in symptomatic patients who do not want to have children. Progestins, synthetic progestational agents, have been used in the management of symptomatic endometriosis both as primary therapy and as an adjunct to surgical time. A variety of oral agents have been employed in this regard and investigators have demonstrated differing degrees of benefit. The lack of a standardized instrument to evaluate painful symptoms makes comparative analysis more difficult. Concern about efficacy and side effect has pushed the research on the development of new well-tolerated drugs and to develop new administration routes to minimize general side effects. Aim of the present review is to present the results of clinical studies on new trends of progestins in the treatment of endometriosis.

Chinese abstract

口服避孕药或孕激素治疗子宫内膜异位症一般安全、有效且耐受性良好，应该成为有症状无生育要求妇女的一线治疗方法。孕激素及孕激素合剂已成为症状性子宫内膜异位症的主要治疗方法，同时也可作为手术期的辅助治疗。如今多种口服药物已应用于临床并使子宫内膜异位症患者不同程度的受益。但由于缺乏评估疼痛程度的标准化方法，使得比较分析较困难。因此对药物有效性和副反应的关注促进我们研发新型且耐药性良好的药物，同时设计出新型的给药途径来降低常见的副作用。本综述主要目的是介绍孕激素在治疗子宫内膜异位症临床研究结果方面的新趋势。

• Chronic pain
• dienogest
• endometriosis
• etonorgestel
• levonorgestrel
• progestins