Effects of estradiol valerate and dienogest on quality of life and sexual function according to age.

Abstract

This is an observational study on 102 women aged 25–45 years to evaluate if the E2V/DNG pill has any impact on quality of life (QoL) and sexual function (FSF). Thirty-nine women were younger than 35 years (group A), and 63 women were 35 years old or older (group B). At baseline and after 6 months, patients received the Italian validated version of the Short Form-36 questionnaire and the Italian validated version of the Female Sexual Function Index questionnaire. Group A showed an overall higher perception in all QoL scores at baseline and after 6-months (p < 0.05). E₂V/DNG treatment did not exert any significant effect on QoL perception in group A apart from an increase in the GH domain (general health). In group B we observed a significant improvement both in GH and in VT (vitality) scores. We found a significant reduction in “lubrication” after 6 months both in group A and B (p < 0.01) and a significant improvement in “satisfaction” and “pain” scores in group A and in “desire”, “satisfaction” and “total” score in group B (p < 0.01). The E2V/DNG pill is associated with a significant improvement of GH and VT and with an improvement in FSF with no difference between age groups.

Chinese abstract

这是一项关于戊酸雌二醇/地诺孕素是否对年龄在25岁–45岁的102名女性生活质量（QOL）和性功能（FSF）有影响的观察性研究。39名女性小于35岁（A组），63名女性大于35岁或更大（B组）。在未用药和用药6个月后，患者接受意大利版的36个问卷调查和女性性功能指数问卷调查。未用药及用药6个月后（p<0.05），A组显示总体的生活质量评分更高。除了提高GH（一般健康状况）外，戊酸雌二醇/地诺孕素对A组生活质量没有任何明显影响。我们观察到B组GH和VT（体力）评分明显升高。我们发现6个月后A组和B组（p<0.01）“性润滑”作用明显降低，A组“性满意度”和“性交疼痛”评分明显升高；B组“性欲”、“性满意度”和“总”评分（p<0.01）明显升高。戊酸雌二醇/地诺孕素明显改善GH和VT，在不同年龄组中对性功能的改善没有显著差异。

• Contraception
• dienogest
• lifestyle
• natural-oestrogen
• sexuality