Advanced thyroid carcinoma in pregnancy: case report of two pregnancies

Abstract

Differentiated thyroid carcinoma is one of the most frequently diagnosed cancers during pregnancy, second only to breast cancer. Therefore, it would be of value to determine if there are pregnancy-related physiological effects that impact long-term prognosis for patients with this disease. Hormone effects attributable to β-human chorionic gonadotropin and estrogens seem particularly likely. We present a case of a 40-year-old woman with thyroid follicular carcinoma with accompanying bone metastases. The cancer was discovered immediately after childbirth and the woman became pregnant again when the disease was in an advanced stage. We describe the cancer evolution and present the maternal and fetal results. Pregnancy in women with advanced thyroid carcinoma could affect long-term prognosis. However, more studies are needed to evaluate this hypothesis. In this unique case, there were two pregnancies and the second occurred in an advanced state of the disease. We evaluated how these pregnancies could affect short-term prognosis of the disease.

Chinese abstract

分化型甲状腺癌是最常见的妊娠期诊断的癌症之一，仅次于乳腺癌。因此，确定是否存在妊娠相关生理影响这种疾病患者的远期预后是有价值的。激素作用很可能归因于人绒毛膜促性腺激素和雌激素。我们介绍一例诊断为甲状腺滤泡癌合并骨转移的40岁的女性患者的病例。癌症是在分娩以后即刻被发现的，当癌症病变处于晚期的时候，她又再次怀孕。我们描述了癌症的发展和母儿预后。诊断甲状腺癌晚期的妊娠妇女可以影响疾病的长期预后。然而需要更多的研究来证实这一假说。这个独特的病例有两次妊娠，第二次是在甲状腺癌处在晚期时。我们评估了妊娠是如何影响这些疾病的短期预后的。

• Fetal monitoring
• pregnancy
• prognosis
• thyroid carcinoma

Declaration of interest

The authors report no conflicts of interest.